small molecular weight compound Search Results


er stress inhibitor tudca  (TargetMol)
94
TargetMol er stress inhibitor tudca
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Er Stress Inhibitor Tudca, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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epigenetic modification  (TargetMol)
93
TargetMol epigenetic modification
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Epigenetic Modification, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tailored low molecular weight diketopyrrolopyrrole compounds  (Verlag GmbH)
90
Verlag GmbH tailored low molecular weight diketopyrrolopyrrole compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Tailored Low Molecular Weight Diketopyrrolopyrrole Compounds, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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high molecular weight compounds  (Wassen International Limited)
90
Wassen International Limited high molecular weight compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
High Molecular Weight Compounds, supplied by Wassen International Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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low-molecular weight carbonyl compounds (including formaldehyde)  (Riemer Environmental)
90
Riemer Environmental low-molecular weight carbonyl compounds (including formaldehyde)
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Low Molecular Weight Carbonyl Compounds (Including Formaldehyde), supplied by Riemer Environmental, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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low molecular weight compounds (aldehydes, ketones, and lactones)  (Semma Therapeutics)
90
Semma Therapeutics low molecular weight compounds (aldehydes, ketones, and lactones)
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Low Molecular Weight Compounds (Aldehydes, Ketones, And Lactones), supplied by Semma Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compound ae90015  (Lundbeck)
90
Lundbeck compound ae90015
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Compound Ae90015, supplied by Lundbeck, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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fluorine-containing low-molecular weight organic chemical compound a  (Omnova Solutions Inc)
90
Omnova Solutions Inc fluorine-containing low-molecular weight organic chemical compound a
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Fluorine Containing Low Molecular Weight Organic Chemical Compound A, supplied by Omnova Solutions Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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low-molecular weight tool compounds  (Novartis)
90
Novartis low-molecular weight tool compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Low Molecular Weight Tool Compounds, supplied by Novartis, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecular weight compound library  (Chembridge)
90
Chembridge small molecular weight compound library
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Small Molecular Weight Compound Library, supplied by Chembridge, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecular compounds  (ChemNavigator com Inc)
90
ChemNavigator com Inc small molecular compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Small Molecular Compounds, supplied by ChemNavigator com Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a-1 polyamideimide molecular weight:  (Hitachi Ltd)
90
Hitachi Ltd a-1 polyamideimide molecular weight:
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
A 1 Polyamideimide Molecular Weight:, supplied by Hitachi Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).

Journal: Stem Cells International

Article Title: Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1 α Branch of the Endoplasmic Reticulum Stress Response

doi: 10.1155/2023/4483776

Figure Lengend Snippet: Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).

Article Snippet: A549 cells were treated with TGF- β 1 (10 ng/ml, 100-21, PeproTech, Rocky Hill, NJ, USA) for 72 hr with or without pretreatment with the ER stress inhibitor TUDCA (100 μ M, abs816166; Absin, Shanghai, China) or IRE1 α -specific inhibitor 4 μ 8c (10 μ M, T6363, Topscience, Shanghai, China) for 1 hr.

Techniques: Expressing, Western Blot, Software, Control